Endocrine Abstracts

Background: Diabetic retinopathy (DR) is one of the most common complications resulting from uncontrolled diabetes mellitus (DM). DR is the leading cause of blindness and low vision. DR is usually diagnosed at an advanced stage, so despite the individual treatment, it is only possible to slow down the progression of DR. Therefore, new potential biomarkers are needed for an earlier DR prognosis to prevent the development of DR. According to the latest studies, ubiquitin-proteas...

Background: Diabetes-induced prolonged elevated plasma glucose levels result in the formation and accumulation of complex and heterogeneous groups of compounds - advanced glycation end-products (AGEs). AGEs normally accumulate slowly, but this process occurs at a faster rate in patients with conditions such as diabetes or cardiovascular disease. Accumulation of AGEs increases oxidative stress and induces an inflammatory reaction, which has a significant influence on the exacer...

BackgroundDiabetic retinopathy is the leading cause of blindness in working-age adults in developed world. Derangements of ubiquitine-proteasome system and telomere length have been associated with microangiopathy in diabetes. Until now, limited data are available on above markers in diabetic retinopathy in type 1 diabetes (T1D).AimThe aim of this work was to compare serum proteasome concentration and telomer...